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ea0081p19 | Adrenal and Cardiovascular Endocrinology | ECE2022

The endocrine society practice guideline revisited: why do nowadays patients undergo screening for cushing’ syndrome, and with which outcome?

Braun Leah , Vogel Frederick , Zopp Stephanie , Marchant Seiter Thomas , Rubinstein German , Berr Christina M. , Kunzel Heike , Beuschlein Felix , Reincke Martin

Background: Cushings syndrome (CS) is a rare but very severe condition with high morbidity and mortality. Patients are often diagnosed late in the course of the disease, many years after onset of symptoms. New approaches like extended screening of at risk populations, alternative biomarkers and clinical scores have been developed to improve diagnostic accuracy. However, there is still a debate, whether certain patient populations should be screened for CS outside the fra...

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ea0090ep802 | Pituitary and Neuroendocrinology | ECE2023

Diagnostic and therapeutic challenges in cyclic Cushing’s syndrome: A systematic literature review

Nowak Elisabeth , Vogel Frederick , Albani Adriana , Braun Leah , Rubinstein German , Zopp Stephanie , Ritzel Katrin , Beuschlein Felix , Theodoropoulou Marily , Reincke Martin

Background: Cyclic Cushings syndrome (cCS) is a sub-entity of Cushings syndrome (CS) associated with diagnostic and therapeutic challenges. It describes a condition, in which phases of clear-cut biochemical hypercortisolism are followed by spontaneous troughs of normal or subnormal cortisol secretion. We conducted the first systematic literature review to identify common features of cCS.Methods: We searched MEDLINE (via PubMed) for eligible s...

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ea0075a22 | Adrenal gland | EYES2021

Steroid profiling using liquid chromatography mass spectrometry during adrenal vein sampling in patients with primary bilateral massive adrenal hyperplasia

Zhang Ru , Rubinstein German , Vetrivel Sharmilee , Vogel Frederick , Kroiss Matthias , Deniz Sinan , Osswald Andrea , Knosel Thomas , Kunz Sonja , Bidlingmaier Martin , Sbiera Silviu , Reincke Martin , Riester Anna

Background: Primary bilateral macronodular adrenocortical hyperplasia (PBMAH) is a rare cause of ACTH-independent Cushings syndrome. The clinical application of adrenal venous sampling (AVS) in diagnostic work-up for PBMAH is still controversially discussed. AVS might be useful in evaluating the predominant side and guiding the decision for unilateral adrenalectomy in PBMAH.Objectives: Our aim was to evaluate whether certain metabolites in AVS samp...

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ea0090p811 | Late-Breaking | ECE2023

Comparison of Metyrapone, OSilodrostat and KEToconazolE in the short-term thERapy of endogenous Cushing’s syndrome: preliminary results of the MOSKETEER study

Detomas Mario , Simeoli Chiara , Ceccato Filippo , Aulinas Maso Ana , Dolce Pasquale , Rubinstein German , Antonini Simone , Stelmachowska-Banaś Maria , Minnetti Marianna , Corsello Andrea , Dischinger Ulrich , Di Paola Nicola , Voltan Giacomo , Santos Vives Alicia , Braun Leah , Mazzarella Alessandro , DEUTSCHBEIN Timo , Lania Andrea , Isidori Andrea , Reincke Martin , Carla Scaroni , M Webb Susan , Pivonello Rosario , Fassnacht Martin , Altieri Barbara

Background: Steroid synthesis inhibitors, like metyrapone, osilodrostat, and ketoconazole are used as second-line treatment in all types of endogenous Cushings syndrome (CS). However, a direct comparison of these three drugs is missing. This study aimed to compare these drugs in the short-term therapy of CS.Design: Retrospective multicenter study involving 15 European centers.Methods: Patients with CS treated with metyrapone,...

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ea0093oc14 | Oral communication 2: Neuroendocrinology | EYES2023

Comparison of metyrapone, osilodrostat and ketoconazole in the short-term therapy of endogenous Cushing’s syndrome: Preliminary results of the Mosketeer study

Detomas Mario , Simeoli Chiara , Di Paola Nicola , Mazzarella Alessandro , Pivonello Rosario , Ceccato Filippo , Voltan Giacomo , Scaroni Carla , Aulinas Anna , Santos Alicia , Webb Susan , Rubinstein German , Braun Leah , Reincke Martin , Dolce Pasquale , Antonini Simone , Lania Andrea , Stelmachowska-Banaś Maria , Cylke-Falkowska Karolina , Minnetti Marianna , Isidori Andrea M. , Corsello Andrea , Gilis-Januszewska Aleksandra , Minasyjan Mari , Sambula Lana , Kastelan Darko , Deutschbein Timo , Haberbosch Linus , Dischinger Ulrich , Fassnacht Martin , Altieri Barbara

Background: Steroid synthesis inhibitors, like metyrapone, osilodrostat, and ketoconazole are used as second-line treatment in all types of endogenous Cushings syndrome (CS). However, a direct comparison of these three drugs is missing. This study aimed to compare these drugs in the short-term therapy of CS.Design: Retrospective multicenter study involving 16 centers worldwide.Methods: Patients with CS treated with metyrapone...